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Since the original films were released both Wachowskis came out as trans: Lana in 2012 and Lilly in 2016. There are several trans directors making inroads in Hollywood (especially in TV) with some having established themselves with strong indie films, including Silas Howard with By Hook or By Crook, Yance Ford from Strong Island, and Rhys Ernt’s upcoming Adam. But the fourth installment of The Matrix — with the potential to become a global blockbuster in the vein of the first three — is history in the making for Lana Wachowski.
While the Wachowskis collaborated on the original trilogy, Lana is set to write (along with Aleksandar Hemon and David Mitchell) and direct the fourth installment without her sister. Lilly, who was coming out during Sense8‘s run, exited the Netflix series after the first season, ceding creative control to her sister for season 2 and the movie that followed. Lilly’s departure from the series marked the first time one of them helmed a project without the other.
Reeves and Moss are back for the new installment but there’s no word as to whether or not Laurence Fishburne will be back for the role of Morpheus.

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Lana Wachowski and Lilly Wachowski are American film and TV directors, writers, and producers. The sisters are both trans women. Collectively known as the Wachowskis, they have worked as a writing and directing team through most of their professional film careers. Wikipedia
The Matrix: Keanu Reeves to reprise role for fourth chapter

Keanu Reeves and Carrie-Anne Moss will return in a fourth instalment of sci-fi franchise The Matrix, with Reeves reprising his lead role as hacker Neo.
Matrix co-creator Lana Wachowski will write, direct and produce the film, a third sequel to the original 1999 hit.
Ms Wachowski celebrated The Matrix’s return, saying many of the ideas it explores are “even more relevant now”.
The first three films in the franchise earned more than $1.6bn (£1.3bn) at the global box office.
Warner Bros Pictures Group chairman Toby Emmerich announced the new film on Tuesday, saying the studio “could not be more excited” about its return.
“Lana is a true visionary – a singular and original creative filmmaker – and we are thrilled that she is writing, directing and producing this new chapter”, he said.
The original film was released 20 years ago and told the story of Neo and his discovery that humanity was trapped in a simulated reality. It proved a major hit and spawned two sequels – The Matrix Reloaded and The Matrix Revolutions.
The third instalment was the first film ever to be released simultaneously around the world at the same hour.
Rumours of a fourth chapter have been circulating since 2017, with reports at the time stating that Warner Bros was “in the early stages of developing a relaunch”.
In a statement on Tuesday, Ms Wachowski said she was “very happy to have these characters back in my life and grateful for another chance to work with my brilliant friends.”